IRMS Examines Sickle Cell Disease (SCD) and Fertility

I have recently seen a 17 year-old young woman with SCD, who came in for a consultation with her mother. She has a brother without Sickle Cell Disease (SCD) or trait that is her HLA match, and she is considering HCT (hematopoietic cell transplantation: aka bone marrow transplant). Due to the incidence of ovarian failure…
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PGD (Preimplantation Genetic Diagnosis) vs PGS (Preimplantation Genetic Screening)

IRMS defines this state-of-the-art lab technology to isolate normal embryos Genetic testing of embryos for chromosomal or genetic abnormalities has been possible in IVF laboratories since the early 1990’s. At that time, the term “PGD” was used for all types of this testing, not differentiating between chromosomal abnormalities or a disease. Before long, the terminology…
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Weighty Matters: IRMS in NJ talks about Maternal Weight and Pregnancy

It is now well known that maternal obesity, a high fat diet and a high GWG (gestational weight gain) have harmful effects on fetal metabolic programming; awareness of harmful effects on the fetal brain is less widespread. There are increased odds of cognitive deficits, decreased IQ and intellectual disability by 1.3 to 3.6 fold. Maternal…
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Choosing Between Day 3 vs. Day 5 Embryo Transfer

“You have to be in it to win it.” With all seriousness, I am saying that if no embryo(s) are transferred into a uterus in a fresh IVF/ICSI cycle, there can be no pregnancy (I am excluding embryos biopsied for genetic testing for hopeful thaw and transfer of a normal embryo in the future). I…
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IRMS NJ Examines “The Impact of Obesity on Female Fertility and Pregnancy”

There are numerous risks to women’s fertility to conceive, as well as, increased risks during pregnancy from obesity, and these risks increase with the degree of obesity. Obesity is defined as a pre-pregnancy BMI > 30 Kg/m^2. While diabetes mellitus (DM) increases with obesity, there is still an increase in complications and adverse pregnancy outcomes…
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IRMS NJ explains the acronym ART

ART is an acronym for Assisted Reproductive Technology. In the broadest sense, some consider all treatment for infertility, such as Clomid for ovulation induction, to be ART. It can also include artificial insemination. However, the term usually refers to the advanced technology used in IVF (in vitro fertilization) treatment cycles. In an IVF treatment, the…
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Day 5 vs. Day 3 Embryo Transfer

Day 5 embryo transfer vs. Day 3 embryo transfer vs. “Sorry, no transfer; all of your embryos arrested”. Has this ever happened to you ? Your entire IVF/ICSI cycle “wasted” because you made few embryos that did not survive in the laboratory to become blastocysts (day 5 embryos) so you did not have an embryo…
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