Research Articles

Below is a list of recently published reproduction / infertility related research articles by the scientists at the Institute for Reproductive Medicine and Science.  The articles have been published in peer-reviewed journals.  These can be accessed through a journal database such as Medline on the internet. 

 


Single Sperm Freezing

The following scientific articles contain additional information on Single Sperm Freezing for Extreme Azoospermia:

Cohen J, Garrisi GJ, Congedo-Ferrara TA, Kieck KA, Schimmel TW, Scott RT: Cryopreservation of single human spermatozoa. Human Reproduction, 12, 994-1001, 1997.

Cohen J, Garrisi J: Micromanipulation of gametes and embryos: Cryopreservation of a single human spermatozoon within an isolated zona pellucida. Human Reproduction Update, 3, 453, 1998.

Walmsley R, Cohen J, Ferrara-Congedo T, Reing AM, Garrisi GJ: The first births and ongoing pregnancies associated with sperm cryopreservation within evacuated egg zonae. Human Reproduction, 13 (supplement), 61-70, 1998.

 


Blastocyst Culture

The following scientific articles contain additional information on Blastocyst Culture:

Cohen J, Simons RF, Edwards RG, Fehilly CB, Fishel SB: Pregnancies following the frozen storage of expanding human blastocysts. The Journal of In Vitro Fertilization and Embryo Transfer, 2, 59 - 64, 1985.

Cohen J, Simons RF, Fehilly CB, Fishel SB, Edwards RG, Hewitt J, Rowland GF, Steptoe PC, Webster JM: Birth after replacement of hatching blastocyst cryopreserved at expanded blastocyst stage. The Lancet, 1, 647, 1985.

Alikani M, Calderon G, Tomkin G, Garrisi J, Kokot M, Cohen J. Cleavage anomalies in early human embryos and survival after prolonged culture in-vitro. Human Reproduction, 15, 2634-43, 2000.

 


Assisted Hatching and Fragment Removal

The following scientific articles contain additional information on Assisted Hatching and Fragment Removal:

Cohen J, Elsner C, Kort H, Malter H, Massey J, Mayer MP, Wiemer K: Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Human Reproduction, 5, 7-13, 1990.

Cohen J, Alikani M, Trowbridge J, Rosenwaks Z: Implantation enhancement by selective assisted hatching using zona drilling of embryos with poor prognosis. Human Reproduction, 7, 685-691, 1992.

Alikani M, Cohen J, Tomkin G, Garrisi GJ, Mack C, Scott R: Human embryo fragmentation in vitro and its implications for pregnancy and implantation. Fertility and Sterility, 71, 836-842, 1999.


Egg and Embryo Freezing

The following scientific articles contain additional information on Egg and Embryo Freezing:

Cohen J, Simons RF, Fehilly CB, Fishel SB, Edwards RG, Hewitt J, Rowland GF, Steptoe PC, Webster JM: Birth after replacement of hatching blastocyst cryopreserved at expanded blastocyst stage. The Lancet, 1, 647, 1985.

Cohen J, DeVane GW, Elsner CW, Fehilly CB, Kort HI, Massey JB, Turner TG: Cryopreservation of zygotes and early cleaved human embryos. Fertility and Sterility, 49, 283 - 289, 1988.

Cohen J, Inge KL, Wright G, Wiker SR, Fehilly CB, Turner TB: Duration of cryostorage of human embryos. Journal of In Vitro Fertilization and Embryo Transfer, 5, 301 - 303, 1988.

Cohen J, DeVane G, Elsner CW, Kort HI, Massey JB, Norbury S: Cryopreserved zygotes and embryos and endocrinological factors in the replacement cycle. Fertility and Sterility, 50, 61 - 67, 1988.

Cohen J, Wiemer KE, Wright G: Prognostic value of morphological characteristics of cryopreserved embryos: a study using videocinematography. Fertility and Sterility, 49, 827 - 834, 1988.

Stachecki J, Cohen J, Willadsen SM. Detrimental Effects of Sodium During Oocyte Cryopreservation. Biology of Reproduction, 59, 395-400, 1998.

Stachecki, Cohen, Willadsen. Cryopreservation of unfertilized mouse oocytes: cryobiological principles and solutions. Cryobiology, 37, 346-54, 1998.

 


PGD for Aneuploidy

The following scientific articles contain additional information on Preimplantation Genetic Diagnosis (PGD) for aneuploidy:

Cohen J, Alikani M, Trowbridge J, Rosenwaks Z (1992): Implantation enhancement by selective assisted hatching using zona drilling of embryos with poor prognosis. Human Reproduction, 1992;7:685-691.

Cohen J, Scott R, Alikani M. Schimmel T, Munné S, Levron J, Wu L, Brenner C, Warner C, Willadsen S (1998) Ooplasmic transfer in mature human oocytes. Molecular human reproduction. 4: 269-280

Dailey T, Dale B, Cohen J and Munné S (1996) Association between non-disjunction and maternal age in meiosis-II human oocytes detected by FISH analysis. Am.J.Hum.Genet, 59:176-184

Gianaroli L, Magli MC, Ferraretti AP, Fiorentino A, garrisi J, Munné S (1997) Preimplantation genetic diagnosis increases the implantation rate in human in vitro fertilization by avoiding the transfer of chromosomally abnormal embryos. Fertil.Steril. 68:1128-1131

Gianaroli L, Magli MC, Ferraretti AP, Munné S (1999) Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with poor prognosis: identification of the categories to which it should be proposed. Fertil. Steril. 72:837-844

Grifo JA, Tang YX, Munné S, Alikani M, Cohen J, Rosenwaks Z (1994) Healthy deliveries from biopsied human embryos. Hum.Reprod. 9:912-916

Hardy K, Martin KL, Leese HJ, Winston RML, Handyside AH (1990) Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage. Human Reprod. 5,6:708-714

Márquez C, Cohen J, Munné S (1998) Chromosome identification on human oocytes and polar bodies by spectral karyotyping. Cytogenet Cell Genet 81:254-258

Márquez C, Sandalinas M, Bahçe M, Alikani M, Munné S (2000) Chromosome abnormalities in 1255 cleavage-stage human embryos. Reproductive Biomedicine Online 1:17-27

Munné S, Lee A, Rosenwaks Z, Grifo J, Cohen J (1993) diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod 8:2185-2191

Munné S, Weier HUG, Grifo J, Cohen J (1994) Chromosome mosaicism in human embryos. Biol. Reprod. 51:373-379

Munné S, Sultan KM, Weier HUG, Grifo J, Cohen J, Rosenwaks Z (1995) Assessment of numerical abnormalities of X, Y, 18 and 16-chromosomes in preimplantation human embryos prior transfer. Am. J. Obs. Gyn 172:1191-1201

Munné S, Dailey T, Sultan KM, Grifo J, Cohen J.(1995) The use of first polar bodies for preimplantation diagnosis of aneuploidy. Human Reprod. 10:1015-1021

Munné S, Alikani M, Tomkin G, Grifo J, Cohen J (1995) Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil.Steril., 64:382-391

Munné S, Weier, U (1996) Simultaneous enumeration of chromosomes 13, 18, 21, X and Y in interphase cells for preimplantation genetic diagnosis of aneuploidy. Cytogenet. Cell. Genet 75:263-270

Munné S, Magli C, Adler A, Wright G, de Boer K, Mortimer D, Tucker M, Cohen J, Gianaroli L (1997) Treatment-related chromosome abnormalities in human embryos. Human Reprod, 12:780-784

Munné S, Scott R, Sable D, Cohen J (1998) First pregnancies after pre-conception diagnosis of translocations of maternal origin. Fertil Steril 69:675-681

Munné S, Morrison L, Fung J, Márquez C, Weier U, Bahçe M, Sable D, Grundfelt L, Schoolcraft B, Scott R, Cohen J (1998). Spontaneous abortions are reduced after pre-conception diagnosis of translocations. JARG:290-296

Munné S, Magli C, Bahçe M, Fung J, Legator M, Morrison L, Cohen J, Gianaroli L (1998) Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22. Prenat Diagn. 18:1459-1466

Munné S and Cohen J (1998) Chromosome abnormalities in human embryos. Human Reprod Update. 4: 842-855

Munné S, Magli C, Cohen J, Morton P, Sadowy S, Gianaroli L, Tucker M, Márquez C, Sable D, Ferraretti AP, Massey JB, Scott R (1999) Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Human Reprod, 14:2191-2199

Munné S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J (2000) Outcome of preimplantation genetic diagnosis of translocations. Fertil Steril. 73:1209-1218

Munné S, Sepulveda S, Balmaceda J, Fernandez E, Fabres C, Mackenna A, Lopez T, Crosby JA, Zegers-Hochschild F (2000) Selection of the most common chromosome abnormalities in oocytes prior to ICSI. Prerat Diagn 20:582-586

Munné S, Escudero T, Sandalinas M, Sable D, Cohen J (2000) Gamete segregation in female carriers of Robertsonian translocations. Cytogenet Cell Genet 90:303-308

Munné S, Sandalinas M, Escudero T, Marquez C, Cohen J (2002) Chromosome mosaicism in cleavage stage human embryos: evidence of a maternal age effect. Reprod Biomed Online 4:223-232

Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munné S. (2001) Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Human Reprod, 16:1954-1958

Wells D, Escudero T, Levy B, Hirschhorn K, Delhanty JDA, Munné S (2002) First clinical application of comparative genome hybridization (CGH) and polar body testing for Preimplantation genetic diagnosis (PGD) of aneuploidy. Fertil Steril In press.

Verlinsky Y, Handyside J, Grifo J, Munné S, Cohen J, et al. (1994) Preimplantation diagnosis of genetic and chromosomal disorders. J. Assisted Reprod. Genet. 11:236-243

Verlinsky Y, Cieslak J, Ivakhnenko V, et al. (1996b) Birth of healthy children after preimplantation diagnosis of common aneuploidies by polar body fluorescent in-situ hybridization analysis. Fertil. Steril. 66:126-129

Willadsen S, Levron J, Munné S, Schimmel T, Márquez C, Scott R, Cohen J (1999) Rapid Visualization of Metaphase Chromosomes in Single Human Blastomeres After Fusion with In Vitro Matured Bovine Eggs. Human Reprod 14:470-475


PDG for Translocations

The following scientific articles contain additional information on Preimplantation Genetic Diagnosis (PGD) for translocations:

Munné S, Scott R, Berg P, Cohen J (1996). First pregnancies after polar body biopsy for testing of chromosome translocations. Fertil. Steril. 66: Suppl: S1 (O-001). This paper obtained the General Program Prize paper of the American Society for Reproductive Medicine. 52d Annual Meeting (Boston, MA, 4 Nov 1996).

Munné S, Scott R, Sable D, Cohen J (1998a). First pregnancies after pre-conception diagnosis of translocations of maternal origin. Fertility and Sterility, 69, 675-681.

Munné S, Fung J, Cassel MJ, Márquez C, Weier HUG (1998b). Preimplantation genetic analysis of translocations: case-specific probes for interphase cell analysis. Human Genetics, 102, 663-674.

Munné S, Morrison L, Fung J, Márquez C, Weier U, Bahçe M, Sable D, Grundfelt L, Schoolcraft B, Scott R, Cohen J (1998c). Spontaneous abortions are reduced after pre-conception diagnosis of translocations. Journal of Assisted Reproduction and Genetics, 15, 290-295.

Willadsen S, Levron J, Munné S, Schimmel T, Márquez C, Scott R, Cohen J (1999). rapid visualization of metaphase chromosomes in single human blastomeres After Fusion with In Vitro Matured Bovine Eggs. Human Reproduction, 14, 470-475.

Weier HUG, Munné S, Fung J (1999). Patient-specific probes for preimplantion genetic diagnosis (PGD) of structural and numerical aberrations in interphase cells. Journal of Assisted Reproduction and Genetics, 16, 182-191.

Gianaroli L, Magli MC, Munné S, Fortini D, Ferraretti AP (1999). Advantages of day four embryo transfer in patients undergoing preimplantation genetic diagnosis of aneuploidy. Journal of Assisted Reproduction and Genetics, 16, 170-175.

Verlinsky Y, Evsikov S (1999). Karyotyping of human oocytes by chromosomal analysis of the second polar body. Molecular Human Reproduction, 5, 89-95.

Evsikov S, Cieslak MLT, Verlinsky Y (2000). Effect of chromosomal translocations on the development of preimplantation human embryos in vitro. Fertility and Sterility, 74, 672-677.

Munné S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J (2000). Outcome of preimplantation genetic diagnosis of translocations. Fertility and Sterility, 73, 1209-1218.

Escudero T, Lee L, Carrel D, Blanco J, Munné S (2000). Analysis of chromosome abnormalities in sperm and embryos from two 45,XY,(t13;t14)(q10;q10) carriers. Prenatal Diagnosis, 20, 599-602.

Munné S, Escudero T, Sandalinas M, Sable D, Cohen J (2000). Gamete segregation in female carriers of Robertsonian translocations. Cytogenetics and Cell Genetics, 90, 303-308.

 


Cytoplasmic Transfer

The following scientific articles contain additional information on Cytoplasmic Transfer:

Barritt JA, Brenner CA, Malter HE, Cohen J. Related Articles. Mitochondria in human offspring derived from ooplasmic transplantation. Human Reproduction, 2001 Mar; 16 (3), 513-6.

Barritt JA, Brenner CA, Willadsen S, Cohen J. Related Articles. Spontaneous and artificial changes in human ooplasmic mitochondria. Human Reproduction, 2000, Jul; 15 Suppl 2:207-17. Review.

Brenner CA, Barritt JA, Willadsen S, Cohen J. Related Articles. Mitochondrial DNA heteroplasmy after human ooplasmic transplantation. Fertility and Sterility, 2000 Sep; 74 (3), 573-8.

Cohen J, Scott R, Alikani M, Schimmel T, Munné S, Levron J, Wu L, Brenner C, Warner C, Willadsen S. Ooplasmic transfer in mature human oocytes. Molecular Human Reproduction, 1998 Mar; 4 (3), 269-80.

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