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Research Articles


Below is a list of recently published reproduction / infertility related research articles by the scientists at the Institute for Reproductive Medicine and Science.  The articles have been published in peer-reviewed journals.  These can be accessed through a journal database such as Medline on the internet.

Blastocyst Culture

The following scientific article contains additional information on Blastocyst Culture:

Alikani M, Calderon G, Tomkin G, Garrisi J, Kokot M, Cohen J.   Cleavage anomalies in early human embryos and survival after prolonged culture in-vitro. Human Reproduction, 15, 2634-43, 2000.

Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munné S. (2001) Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Human Reprod, 16:1954-1958

Human Embryology

The following scientific articles contain additional information on Human Embryology:

Wiemer KE, Garrisi J, Steuerwald N, Alikani M, Reing AM, Ferrara TA, Noyes N, Cohen, J.  Beneficial effects of co-culture with assisted hatching when applied to multiple-failure in vitro fertilization patients.  Hum Reprod.  1996  Nov;11(11):2429-33.

Cohen J, Garrisi J, Congedo-Ferrara TA, Kieck KA, Schimmel TW, Scott RT.  Cryopreservation of a single human spermatozoa.  Hum Reprod.  1997  May;12(5):994-1001

Cohen J, Garrisi J  Micromanipulation of gametes and embryos:  Cryopreservation of a single human spermatozoon within an isolated zona pellucida.  Hum Reprod Update.  1997  Sep-Oct;3(5):453

Cohen J, Alikani M, Garrisi J, Willadsen S.  Micromanipulation of human gametes and embryos:  ooplasmic donation at fertilization.  Hum Reprod Update.  1998  Mar-Apr;4(2):195-6

Walmsley R, Cohen J. Ferrara-Congedo T, Reing A, Garrisi J.  The first births and ongoing pregnancies associated with sperm cryopreservation within evacuated egg zonae.  Hum Reprod.  1998  Dec:13 Suppl 4:61-70

Alikani M, Cohen J, Tomkin G, Garrisi GJ, Mack C, Scott R: Human embryo fragmentation in vitro and its implications for pregnancy and implantation. Fertility and Sterility, 71, 836-842, 1999.

Blake M, Garrisi J, Tomkin G, Cohen J.  Sperm deposition site during ICSI affects fertilization and development.  Fertil Steril.  2000  Jan;73(1) 31-7

Alikani M, Calderon G, Tomkin G, Garrisi J, Kokot M, Cohen J.  Cleavage anomalies in early human embryos and survival after prolonged culture in vitro.  Hum Reprod.  2000 Dec;15(12):2634-43.

Egg and Embryo Freezing

The following scientific articles contain additional information on Egg and Embryo Freezing:

Stachecki JJ, Cohen J, Garrisi J, Munne S, Burgess C, Willadsen, SM.   Cryopreservation of unfertilized human oocytes.  Reprod Biomed Online. 2006 Aug;13(2):222-7.

Stachecki JJ, Garrisi J, Sabino S, Caetano JP, Wiemer KE, Cohen J.  A new safe, simple, and successful vitrification method for bovine and human blastocysts.  Reprod Biomed Online.  2008  Sep;17(3):360-7

Reproductive Endocrinology

Weghofer A, Munne S, Chen S, Barad D, Gleicher N. Lack of association between polycystic ovary syndrome and embryonic aneuploidy. Fertil Steril. 2007 Oct;88(4):900-5.

Weghofer A, Munne S, Brannath W, Chen S, Tomkin G, Cekleniak N, Garrisi M, Barad D, Cohen J, Gleicher N.  The impact of LH-containing gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation.  HumReprod.  2008  Mar;23(3):499-503

PGD for Aneuploidy

The following scientific articles contain additional information on Preimplantation Genetic Diagnosis (PGD) for aneuploidy:

Gianaroli L, Magli MC, Ferraretti AP, Fiorentino A, Garrisi J, Munné S (1997) Preimplantation genetic diagnosis increases the implantation rate in human in vitro fertilization by avoiding the transfer of chromosomally abnormal embryos. Fertil.Steril. 68:1128-1131

Munne S, Marquez C, Reing A, Garrisi J, Alikani M.  Chromosome abnormalities in embryos obtained after conventional in vitro fertilization and intracytoplasmic sperm injection.  Fertil Steril.  1998  May;69(5):904-8

Munné S, Magli C, Cohen J, Morton P, Sadowy S, Gianaroli L, Tucker M, Márquez C, Sable D, Ferraretti AP, Massey JB, Scott R (1999) Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Human Reprod, 14:2191-2199

Munné S, Escudero T, Sandalinas M, Sable D, Cohen J (2000) Gamete segregation in female carriers of Robertsonian translocations. Cytogenet Cell Genet 90:303-308

Munné S, Sandalinas M, Escudero T, Marquez C, Cohen J (2002) Chromosome mosaicism in cleavage stage human embryos: evidence of a maternal age effect. Reprod Biomed Online 4:223-232

Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munné S. (2001) Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Human Reprod, 16:1954-1958

Wells D, Escudero T, Levy B, Hirschhorn K, Delhanty JDA, Munné S (2002) First clinical application of comparative genome hybridization (CGH) and polar body testing for Preimplantation genetic diagnosis (PGD) of aneuploidy. Fertil Steril  2002 Sep;78(3):543-9.

Munné S, Escudero T, Colls P, Xuezhong Z, Oter M, Garrisi M, Barnes F, Zouves C, Werlin L, Magli C, Cohen J.  Predictability of preimplantation genetic diagnosis of aneuploidy and translocations on prospective attempts. Reprod Biomed Online. 2004 Dec;9(6):645-51.

Munné S, Velilla E, Colls P, Garcia Bermudez M, Vemuri MC, Steuerwald N, Garrisi J, Cohen J. Self-correction of chromosomally abnormal embryos in culture and implications for stem cell production. Fertil Steril. 2005 Nov;84(5):1328-34.

Munne S, Chen S, Colls P, Garrisi J, Zheng X, Cekleniak N, Lenzi M, Hughes P, Fischer J, Garrisi M, Tomkin G, Cohen J.  Maternal age, morphology, development, and chromosome abnormalities in over 6000 cleavage-stage embryos.  Reprod Biomed Online.  2007  May;14(5):628-34

Weghofer A, Munne S, Chen S, Barad D, Gleicher N. Lack of association between polycystic ovary syndrome and embryonic aneuploidy. Fertil Steril. 2007 Oct;88(4):900-5.

Colls P, Escudero T, Cekleniak N, Sadowy S, Cohen J, Munné S. Increased efficiency of preimplantation genetic diagnosis for infertility using "no result rescue". Fertil Steril. 2007 Jul;88(1):53-61.

Munné S, Chen S, Colls P, Garrisi J, Zheng X, Cekleniak N, Lenzi M, Hughes P, Fischer J, Garrisi M, Tomkin G, Cohen J. Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reprod Biomed Online. 2007 May;14(5):628-34.

PDG for Translocations

The following scientific articles contain additional information on Preimplantation Genetic Diagnosis (PGD) for translocations:

Munné S, Scott R, Berg P, Cohen J (1996). First pregnancies after polar body biopsy for testing of chromosome translocations. Fertil. Steril. 66: Suppl: S1 (O-001). This paper obtained the General Program Prize paper of the American Society for Reproductive Medicine. 52d Annual Meeting (Boston, MA, 4 Nov 1996).

Munné S, Scott R, Sable D, Cohen J (1998). First pregnancies after pre-conception diagnosis of translocations of maternal origin. Fertility and Sterility, 69, 675-681.

Munné S, Fung J, Cassel MJ, Márquez C, Weier HUG (1998). Preimplantation genetic analysis of translocations: case-specific probes for interphase cell analysis. Human Genetics, 102, 663-674.

Munné S, Morrison L, Fung J, Márquez C, Weier U, Bahçe M, Sable D, Grundfelt L, Schoolcraft B, Scott R, Cohen J (1998). Spontaneous abortions are reduced after pre-conception diagnosis of translocations. Journal of Assisted Reproduction and Genetics, 15, 290-295.

Willadsen S, Levron J, Munné S, Schimmel T, Márquez C, Scott R, Cohen J (1999). rapid visualization of metaphase chromosomes in single human blastomeres After Fusion with In Vitro Matured Bovine Eggs. Human Reproduction, 14, 470-475.

Weier HUG, Munné S, Fung J (1999). Patient-specific probes for preimplantion genetic diagnosis (PGD) of structural and numerical aberrations in interphase cells. Journal of Assisted Reproduction and Genetics, 16, 182-191.

Gianaroli L, Magli MC, Munné S, Fortini D, Ferraretti AP (1999). Advantages of day four embryo transfer in patients undergoing preimplantation genetic diagnosis of aneuploidy. Journal of Assisted Reproduction and Genetics, 16, 170-175.

Verlinsky Y, Evsikov S (1999). Karyotyping of human oocytes by chromosomal analysis of the second polar body. Molecular Human Reproduction, 5, 89-95.

Evsikov S, Cieslak MLT, Verlinsky Y (2000). Effect of chromosomal translocations on the development of preimplantation human embryos in vitro. Fertility and Sterility, 74, 672-677.

Munné S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J (2000). Outcome of preimplantation genetic diagnosis of translocations. Fertility and Sterility, 73, 1209-1218.

Escudero T, Lee L, Carrel D, Blanco J, Munné S (2000). Analysis of chromosome abnormalities in sperm and embryos from two 45,XY,(t13;t14)(q10;q10) carriers. Prenatal Diagnosis, 20, 599-602.

Munné S, Escudero T, Sandalinas M, Sable D, Cohen J (2000). Gamete segregation in female carriers of Robertsonian translocations. Cytogenetics and Cell Genetics, 90, 303-308.

Munné S, Escudero T, Colls P, Xuezhong Z, Oter M, Garrisi M, Barnes F, Zouves C, Werlin L, Magli C, Cohen J. Predictability of preimplantation genetic diagnosis of aneuploidy and translocations on prospective attempts.    Reprod Biomed Online. 2004 Dec;9(6):645-51.

Chen SH, Escudero T, Cekleniak NA, Sable DB, Garrisi MG, Munne S. Patterns of ovarian response to gonadotropin stimulation in female carriers of balanced translocation. Fertil Steril. 2005 May;83(5):1504-9.